Categories | Nootropic Supplements |
---|---|
Brand Name: | SGH |
Model Number: | 272786-64-8 |
Certification: | GMP, ISO9001,BRC,KOSHER |
Place of Origin: | China |
MOQ: | 10g |
Price: | Negotiation |
Payment Terms: | T/T, Western Union, MoneyGram, Bitcoin |
Supply Ability: | 100kg/Month |
Packaging Details: | Discreet package or foiled bag or pack as customer's request |
CAS NO: | 272786-64-8 |
Synonyms: | Unifiram |
Form: | Powder |
Usage: | Loss weight |
Color: | White |
Storage: | -20C |
Description:
Its compound is known as an AMPAkine due to exerting most of its
actions via the AMPA receptor (one of the three main subsets of
glutamate receptors, alongside NDMA and kainate). This enhancement
of AMPA function seems to also rely on enhancing signalling via the
Glycine binding site of NMDA receptors, although one minimal
signalling goes through the NMDA receptor then the benefits on AMPA
receptors seem dose-dependent.
Sunifiram (DM-235) is a piperazine derived ampakine drug which acts
as a positive allosteric modulator of AMPA receptors, and has
nootropic effects in animal studies with significantly higher
potency than piracetam. A number of related compounds are known,
the best known being unifiram (DM-232). This enhancement by
sunifiram is associated with an increase inphosphorylation of AMPAR
through activation of protein kinase II(CaMKII) and an increase in
phosphorylation of NMDAR through activation of protein kinase C α
(PKCα). More specifically, sunifiram stimulates the glycine-binding
site of NMDAR with concomitant PKCαactivation through Src kinase.
Enhancement of PKCα activity triggers to potentiate hippocampal LTP
through CaMKII activation.
Sunifiram improves cognitive deficits via CaM kinase II andprotein
kinase C activation. Unifiram is a positive allosteric modulator of
your AMPA receptors (also known as
2-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors). As
an Ampakine, Unifiram effects glutamate uptake in the brain causing
better synaptic transmission between neurons. Unifiram also
stimulates acetylcholine production making its mechanism of action
very similar to Noopept, Pramiraceta, Oxiracetam and other racetam
nootropics. There has been less research into Unifiram than its
counterpart Sunifiram, but these two chemicals are closely related
and believed to work in almost identical ways.
Application:
Unifiram is a highly potent AMPAkine-like nootropic with antiamnesic and cognition-enhancing effects in animal studies at up to three orders of magnitude higher potency than piracetam. User reviews and Sunifiram logs point to the fact that this supplement makes information recall much easier and helps you think more clearly. Sunifiram is being compared to Noopept quite a bit because of their similar potency levels. Initial observations suggest that Sunifiram is better as a memory booster while Noopept might have an edge on increasing focus and alertness.
Like the Racetams, Unifiram is believed to improve learning,
memory, concentration, mental energy and basic cognition. We know
that increased levels of glutamate and acetylcholine improves the
health of your brain cells and makes it easier for neurons to send
signals between them. This can result in better processing of
information, more clarity of thought, anti-amnesiac effects and
improved attention span.
In initial studies, Unifiram seems to offer significantly stronger
results compared to other nootropics, however more studies should
be conducted before this supplement enters widespread use. The
first studies on Unifiram were only published in 2002 so research
history is quite limited. That being said, what we do know from the
studies that have been conducted so far is very exciting. In a
research trial conducted on rats exposed to a Morris Water Maze, a
small dosage of Unifiram was able to reverse the effects of an
amnesiac drug administered to the rats. Taking Unifiram increased
their ability to remember the right path to navigate the maze and
also improved performance on a social learning test.
Functions:
Unifiram can Improved Memory
Unifiram can Increased Learning Ability
Unifiram can Improved Cognitive Processing
Unifiram can Heightened Reflexes
Unifiram can Heightened Perception
Unifiram can Reduced Anxiety
Unifiram can Reduced Depression
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